Pair Name	Carnosic acid, Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAD	hsa572
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP8	hsa841
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	TNFRSF10C	hsa8794
	Up-regulation	Expression	TNFRSF10D	hsa8793
	Up-regulation	Expression	TNFSF10	hsa8743
	Up-regulation	Expression	TP53	hsa7157
	Up-regulation	Expression	TP73	hsa7161
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
	T-47D	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0553
In Vivo Model	5×10⁵ MCF-7 cells were subcutaneously injected into the dorsal flanks of athymic nude mice.
Result	Our study supplies a novel therapeutic strategy to induce apoptosis for suppressing breast cancer, which was relied on Caspase-3/TRAIL activation.